Everyone's cystic fibrosis (CF) is different, but ultimately, CF is always working beneath the surface.

Since CF is always working beneath the surface, your or your child’s treatment should be, too.

SYMDEKO is tough on CF, because it targets the underlying cause in people 6 years and older with eligible mutations.

The underlying cause of CF

lung-mapCF is caused by cystic fibrosis transmembrane conductance regulator (CFTR) protein defects. A mutation in the genes of a person with CF may make defective CFTR proteins that:

  • Don’t open correctly
  • Don’t get to the cell surface, where they are normally located

A person with CF may make CFTR proteins that have one or both of these defects.

Because of these defects, chloride ions cannot flow freely into or out of the cells as they should, leading to an imbalance of salt and water. This can lead to thick, sticky mucus in the lungs.


Watch a Video to See How SYMDEKO Works

See how SYMDEKO targets the underlying cause.

SYMDEKO targets the underlying cause

SYMDEKO is made up of tezacaftor and ivacaftor, which work on certain defects of the CFTR protein at the cellular level.


cell main graph
cell main graph
cell main graph

Together, tezacaftor and ivacaftor help certain CFTR proteins work better. This allows more chloride ions to pass into and out of the cells—helping keep a balance of salt and water in certain organs such as the lungs.

What is known about how SYMDEKO works was learned from studies conducted in a laboratory. Keep in mind that results from laboratory studies do not always match how these medicines work in a person. If you have questions about treatment, speak with your healthcare provider.