WHO SYMDEKO® IS FOR

Check Your Eligibility

SYMDEKO is for the treatment of cystic fibrosis (CF) in patients age 6 years and older who have two copies of the F508del mutation, or who have at least one mutation in the CF gene that is responsive to treatment with SYMDEKO. Enter both of your mutations below to see if you're eligible for SYMDEKO.

 

6 years and older
Symdeko Eligibility

We’re sorry, we do not recognize 1 or both of the mutations you entered.

Talk to your healthcare provider to discuss your CF care plan. They can help determine what treatment option is right for you at this time.

Learn how to enter 2 or more mutations.

 

If you don’t know your CF gene mutations, it’s important to work with your healthcare provider to identify them. Knowing your mutations can help determine if SYMDEKO could be right for you.

Check 3Based on the information you entered, you may be eligible for SYMDEKO.

Talk with your healthcare provider to see if SYMDEKO is right for you.

Here is some information about SYMDEKO that may be helpful:

Neither CF gene mutation you entered is eligible for SYMDEKO.

Talk with your healthcare provider to discuss your CF care plan and treatment options that may be right for you.

One of the CF gene mutations you entered is not eligible for SYMDEKO.

Please note, if you only have 1 copy of the F508del mutation, your second CF gene mutation must also be eligible for SYMDEKO.

Talk with your healthcare provider to discuss your CF care plan and treatment options that may be right for you.


See which mutations SYMDEKO is indicated for

SYMDEKO is for the treatment of CF in people age 6 years and older who have two copies of the F508del mutation or one of the following CF gene mutations. If you don't see your mutation in this chart, try using the tool above.

 

546insCTA E92K G576A;R668C L967S R117H S737F
711+3A→G* E116K G622D L997F R117L S912L
2789+5G→A* E193K G970D L1324P R117P S945L*
3272-26A→G* E403D G1069R L1335P R170H S977F*
3849+10kbC→T* E588V G1244E L1480P R258G S1159F
A120T E822K G1249R M152V R334L S1159P
A234D E831X G1349D M265R R334Q S1251N
A349V F191V H939R M952I R347H* S1255P
A455E* F311del H1054D M952T R347L T338I
A554E F311L H1375P P5L R347P T1036N
A1006E F508C I148T P67L* R352Q* T1053I
A1067T F508C;S1251N I175V P205S R352W V201M
D110E F575Y I336K Q98R R553Q V232D
D110H* F1016S I601F Q237E R668C V562I
D192G F1052V I618T Q237H R751L V754M
D443Y F1074L I807M Q359R R792G V1153E
D443Y;G576A;
R668C
F1099L I980K Q1291R R933G V1240G
D579G* G126D I1027T R31L R1066H V1293G
D614G G178E I1139V R74Q R1070Q W1282R
D836Y G178R I1269N R74W R1070W* Y109N
D924N G194R I1366N R74W;D1270N R1162L Y161S
D979V G194V K1060T R74W;V201M R1283M Y1014C
D1152H* G314E L15P R74W;V201M;
D1270N
R1283S Y1032C
D1270N G551D L206W* R75Q S549N  
E56K G551S L320V R117C* S549R  
E60K G576A L346P R117G S589N  
546insCTA L346P
711+3A→G* L967S
2789+5G→A* L997F
3272-26A→G* L1324P
3849+10kbC→T * L1335P
A120T L1480P
A234D M152V
A349V M265R
A455E* M952I
A554E M952T
A1006E P5L
A1067T P67L*
D110E P205S
D110H* Q98R
D192G Q237E
D443Y Q237H
D443Y;G576A;
R668C
Q359R
D579G* Q1291R
D614G R31L
D836Y R74Q
D924N R74W
D979V R74W;D1270N
D1152H* R74W;V201M
D1270N R74W;V201M;
D1270N
E56K R75Q
E60K R117C*
E92K R117G
E116K R117H
E193K R117L
E403D R117P
E588V R170H
E822K R258G
E831X R334L
F191V R334Q
F311del R347H*
F311L R347L
F508C R347P
F508C;S1251N R352Q*
F575Y R352W
F1016S R553Q
F1052V R668C
F1074L R751L
F1099L R792G
G126D R933G
G178E R1066H
G178R R1070Q
G178R R1070W*
G194V R1162L
G314E R1283M
G551D R1283S
G551S S549N
G576A S549R
G576A;R668C S589N
G622D S737F
G970D S912L
G1069R S945L*
G1244E S977F*
G1249R S1159F
G1349D S1159P
H939R S1251N
H1054D S1255P
H1375P T338I
I148T T1036N
I175V T1053I
I336K V201M
I601F V232D
I618T V562I
I807M V754M
I980K V1153E
I1027T V1240G
I1139V V1293G
I1269N W1282R
I1366N Y109N
K1060T Y161S
L15P Y1014C
L206W* Y1032C
L320V  

*Clinical data exists for these mutations. See clinical studies

Complex/compound mutations. Most people with CF have 2 CF mutations, 1 on each copy of the CF gene. However, in rare instances, 1 copy of the CF gene can have more than 1 mutation. This is called a compound, or complex, mutation.

 

If you don't know your mutation, talk to your healthcare provider to learn if you have an indicated CF gene mutation.
It is not known if SYMDEKO is safe and effective in children under 6 years of age.