WHO SYMDEKO® IS FOR

Check Your Eligibility

SYMDEKO is for the treatment of cystic fibrosis (CF) in patients age 6 years and older who have two copies of the F508del mutation, or who have at least one mutation in the CF gene that is responsive to treatment with SYMDEKO. Enter both of your mutations below to see if you're eligible for SYMDEKO.
 

6 years and older

See if the CF gene mutation you entered is correct and search again.

You can view the list of eligible SYMDEKO mutations below.

If you don’t know your CF gene mutations, it’s important to work with your healthcare provider to identify them. Knowing your mutations can help determine if SYMDEKO could be right for you.

Based on the information you entered, you may be eligible for SYMDEKO.

Talk with your healthcare provider to see if SYMDEKO is right for you. You can view the list of eligible mutations below.

Here is some information about SYMDEKO that may be helpful:

Neither CF gene mutation you entered is eligible for SYMDEKO.

Talk with your healthcare provider to discuss your CF care plan and treatment options that may be right for you.

You can view the list of eligible mutations below.

One of the CF gene mutations you entered is not eligible for SYMDEKO.

Please note, if you only have 1 copy of the F508del mutation, your second CF gene mutation must also be eligible for SYMDEKO.

Talk with your healthcare provider to discuss your CF care plan and treatment options that may be right for you.

You can view the list of eligible mutations below.

See which mutations SYMDEKO is indicated for

F508del/F508del
c.1521_1523delCTT/c.1521_1523delCTT

OR

At least 1 other responsive mutation from the following list:

711+3AG
c.579+3A>G
A455E
c.1364C>A
D579G
c.1736A>G
E193K
c.577G>A
K1060T
c.3179A>C
R117C
c.349C>T
S945L
c.2834C>T
2789+5GA
c.2657+5G>A
A1067T
c.3199G>A
D1152H
c.3454G>C
E831X
c.2491G>T
L206W
c.617T>G
R347H
c.1040G>A
S977F
c.2930C>T
3272-26AG
c.3140-26A>G
D110E
c.330C>A
D1270N
c.3808G>A
F1052V
c.3154T>G
P67L
c.200C>T
R352Q
c.1055G>A
 
3849+10kbCT
c.3718-2477C>T
D110H
c.328G>C
E56K
c.166G>A
F1074L
c.3222T>A
R74W
c.220C>T
R1070W
c.3208C>T
 

 

711+3AG
c.579+3A>G
A455E
c.1364C>A
D579G
c.1736A>G
K1060T
c.3179A>C
E193K
c.577G>A
R117C
c.349C>T
S945L
c.2834C>T
2789+5GA
c.2657+5G>A
A1067T
c.3199G>A
D1152H
c.3454G>C
E831X
c.2491G>T
L206W
c.617T>G
R347H
c.1040G>A
S977F
c.2930C>T
3272-26AG
c.3140-26A>G
D1270N
c.3808G>A
D110E
c.330C>A
F1052V
c.3154T>G
P67L
c.200C>T
3849+10kbCT
c.3718-2477C>T
R352Q
c.1055G>A
D110H
c.328G>C
E56K
c.166G>A
F1074L
c.3222T>A
R74W
c.220C>T
R1070W
c.3208C>T

 

The following mutations were not included in the clinical studies but are predicted to respond based on results from a laboratory setting: A1067T, E56K, F1074L, D110E, E193K, K1060T, D1270N, F1052V, R74W.

If you don't know your mutation, talk to your healthcare provider to learn if you have an indicated CF gene mutation.
It is not known if SYMDEKO is safe and effective in children under 6 years of age.